Does a Pickup Truck Need Form 2290?

Almost never. A standard pickup, even a heavy one ton model, has a taxable gross weight well under 55,000 pounds, so it does not file Form 2290.

When weight changes the answer

Filing depends on taxable gross weight, not on what the vehicle is called. If a pickup is built up, or is combined with heavy trailers so the powered vehicle reaches 55,000 pounds, then the powered vehicle could be subject. That is rare for a pickup, but the weight is what decides it, so check the number if you are unsure.